UDP-GlcNAc

Description

UDP-GlcNAc is a nucleotide sugar consisting of the nucleotide uridine 5'-diphosphate and a phosphate-bound monosaccharide, N-acetylglucosamine. Nucleotide sugars are the activated forms of monosaccharides required for cellular metabolism and biosynthesis reactions. UDP-GlcNAc serves as a donor substrate for N-acetylglucosaminyltransferases in the biosynthesis of N-acetylglucosamine-containing glycans.

Appearance

Lyophilized white powder, hygroscopic

Purity

≥ 90% (HPLC-UV). Product has not been tested for endotoxins

Solubility

Clear (>50 mg/mL, H2O)

Storage

-20°C

Special instructions

For research use only! Intended use for in vitro laboratory applications.

Toxicity & Safety

Not a hazardous substance or mixture according to Regulation (EC) No 1272/2008.

Selected References

Rexer, T.;  Laaf, D.;  Gottschalk, J.;  Frohnmeyer, H.;  Rapp, E.; Elling, L., Enzymatic Synthesis of Glycans and Glycoconjugates. In Advances in Biochemical Engineering/Biotechnology, 2021; Vol. 175, pp 231-280.

Mahour, R.;  Klapproth, J.;  Rexer, T. F. T.;  Schildbach, A.;  Klamt, S.;  Pietzsch, M.;  Rapp, E.; Reichl, U., Establishment of a five-enzyme cell-free cascade for the synthesis of uridine diphosphate N-acetylglucosamine. J Biotechnol 2018, 283, 120-129.